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目的探讨急性冠状动脉综合征患者血清高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、B型脑钠肽(B-type natriuretic peptide,BNP)、D-二聚体水平变化及其临床意义。方法 87例急性冠状动脉综合征患者依据冠状动脉造影检查结果分为正常组22例,冠心病组65例,冠心病组中不稳定型心绞痛24例(UAP组),急性心肌梗死23例(AMI组),稳定型心绞痛18例(SAP组)。分别应用全自动免疫比浊法、化学发光免疫法、ELISA法检测4组血清hs-CRP,BNP,D-二聚体水平,并进行比较。结果 AMI和UAP组血清hs-CRP,BNP,D-二聚体水平高于正常组及SAP组(P<0.05或P<0.01);SAP组各指标水平与正常组比较差异无统计学意义(P>0.05);AMI组各指标水平高于UAP组,但差异无统计学意义(P>0.05)。结论 hs-CRP,BNP及D-二聚体是诊断急性冠状动脉综合征的敏感指标。
Objective To investigate the changes of serum high-sensitivity C-reactive protein (hs-CRP), B-type natriuretic peptide (BNP) and D-dimer in patients with acute coronary syndrome Clinical significance. Methods A total of 87 patients with acute coronary syndrome (ACS) were divided into two groups according to coronary angiography: 22 in the normal group, 65 in the CHD group, 24 in the UAP group and 23 in the AMI group (AMI Group), 18 cases of stable angina pectoris (SAP group). The levels of hs-CRP, BNP and D-dimer in serum of four groups were detected by automatic immunoturbidimetry, chemiluminescence immunoassay and ELISA respectively. Results The levels of serum hs-CRP, BNP and D-dimer in AMI and UAP group were higher than those in normal group and SAP group (P <0.05 or P <0.01). There was no significant difference in each index between SAP group and normal group P> 0.05). The level of each index in AMI group was higher than that in UAP group, but the difference was not statistically significant (P> 0.05). Conclusion hs-CRP, BNP and D-dimer are sensitive indicators for the diagnosis of acute coronary syndrome.