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目的评估腹腔冲洗细胞学检查(PLC)对胃癌预后判断的价值。方法收集胃癌及对照组患者的腹腔冲洗液标本,采用不同方法检测其中的游离癌细胞,并评价其与临床病理参数的关系。结果PLC检测阳性率为31.8%,经相关分析,胃癌患者PLC阳性率与下列4种参数均成正相关:肿瘤分化程度(P<0.05),浸润深度(P<0.01),淋巴结转移(P<0.01),TNM分期(P<0.05)。而与肿瘤的大小无关;肿瘤大小分组间差异无统计学意义(P>0.05)。检测阳性组与阴性组术后1年复发率和生存率比较,差异均有统计学意义。结论PLC检测可作为判断胃癌侵袭转移、术后复发情况及患者预后的参考指标之一。
Objective To assess the value of peritoneal lavage cytology (PLC) in the prognosis of gastric cancer. Methods The specimens of peritoneal lavage fluid collected from patients with gastric cancer and control group were collected. The free cancer cells were detected by different methods and their relationship with clinicopathological parameters was evaluated. Results The positive rate of PLC test was 31.8%. According to the correlation analysis, the positive rate of PLC in gastric cancer patients was positively correlated with the following four parameters: tumor differentiation (P <0.05), depth of invasion (P <0.01), lymph node metastasis ), TNM stage (P <0.05). But not with tumor size. There was no significant difference between tumor size groups (P> 0.05). The positive rate of recurrence and the survival rate of the positive group and the negative group were statistically significant at 1 year after operation. Conclusion PLC test can be used as a reference index to determine the invasion and metastasis of gastric cancer, postoperative recurrence and prognosis of patients.