核苷转运是指细胞外的核苷通过细胞膜进入细胞。转运是细胞利用外源性核苷的第一步,抑制核苷转运将导致抑制核苷的摄取和掺入。已报道的核苷转运抑制剂有潘生丁(Dipyridamole)、硝基苄基硫代肌苷(Nitro-benzylthioinosine,简称NBMPR)等。核苷转运抑制剂有可能增强抗代谢物的抗肿瘤作用。抗肿瘤抗生素Acivicin是抑制嘌呤和嘧啶合成的抗代谢物,在培养液中加入鸟苷、胞苷和脱氧胞苷,Acivicin对肿瘤细胞的抑制作用在很大程度上被抵消;如同时加入潘生丁,则减少核苷的抵消作用,从而保持了 Nucleoside transport means that extracellular nucleosides enter the cell through the cell membrane. Transport is the first step in the use of exogenous nucleosides by cells and inhibition of nucleoside transport will result in inhibition of uptake and incorporation of nucleosides. Reported nucleoside transport inhibitors are Dipyridamole, Nitro-benzylthioinosine (NBMPR) and so on. Nucleoside transport inhibitors may enhance the anti-tumor effect of antimetabolites. Anti-tumor antibiotics Acivicin is an anti-metabolite that inhibits the synthesis of purine and pyrimidine. The addition of guanosine, cytidine and deoxycytidine to the culture medium greatly inhibits the inhibitory effect of Acivicin on tumor cells. For example, adding dipyridamole, Then reduce the effect of nucleoside offset and thus maintained