目的研究PTEN和Ki-67蛋白在脑星形细胞瘤中表达情况以及临床意义。方法用免疫组化方法检测15例正常脑组织和65例脑星形细胞瘤组织中PTEN和Ki-67蛋白的表达情况。结果PTEN蛋白在脑星形细胞瘤表达随WHO分级增高而降低。Ki-67表达水平随脑星形细胞瘤病理分级的增高而增高。脑星形细胞瘤组织中PTEN与Ki-67蛋白的表达均呈负相关。结论PTEN表达缺失可引起Ki-67的过表达,促进脑星形细胞瘤血管生成和肿瘤细胞增殖,两者在肿瘤的增殖、侵袭过程中相互作用。 Objective To investigate the expression and clinical significance of PTEN and Ki-67 in brain astrocytoma. Methods The expression of PTEN and Ki-67 in 15 cases of normal brain tissue and 65 cases of brain astrocytoma were detected by immunohistochemistry. Results The expression of PTEN protein in brain astrocytomas decreased with WHO classification. The expression of Ki-67 increased with the pathological grade of astrocytoma. There was a negative correlation between the expression of PTEN and Ki-67 in brain astrocytoma. Conclusions The loss of PTEN expression can induce the over-expression of Ki-67 and promote the angiogenesis and tumor cell proliferation in astrocytoma. Both of them play an important role in the process of tumor proliferation and invasion.