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目的：研究青蒿素（Ａｒｔ）对豚鼠心室肌细胞外向整流钾电流的作用．方法：以全细胞膜片箝技术观察Ａｒｔ对快速延迟整流钾电流（ＩＫｒ）和缓慢延迟整流钾电流（ＩＫｓ）的作用．结果：Ａｒｔ剂量依赖性抑制时间依赖性外向钾电流（ＩＫｓｔｅｐ）和ＩＫｔａｉｌ．Ａｒｔ５０μｍｏｌ·Ｌ－１在＋４０ｍＶ时，使ＩＫｓｔｅｐ从３８７±４６ｐＡ减少到２４０±４８ｐＡ，ＩＫｔａｉｌ从２９９±３０ｐＡ减少到１３０±３８ｐＡ．结论：Ａｒｔ抑制外向钾电流的两种成分ＩＫｓ和ＩＫｒ．
4. Objective : To study the effect of artemisinin (Art) on outward rectifier potassium current in guinea pig ventricular myocytes. METHODS: The effect of Art on fast delayed rectifier potassium current (IKr) and slow delayed rectifier potassium current (IKs) was observed by whole-cell patch clamp technique. RESULTS: Art dose-dependently inhibited the time-dependent outward potassium current (IKstep) and IKtail. Art50μmol·L-1 decreased IKstep from 387±46pA to 240±48pA at +40mV, and IKtail decreased from 299±30pA to 130±38pA. Conclusion: Art inhibits the two components of outward potassium current IKs and IKr.