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弓形虫病是人畜共患病,受环境污染及生活方式等因素影响,近年发病率呈现持续增高趋势。为此,本研究探索弓形虫感染对大鼠脑组织神经丝mRNA表达及细胞免疫水平的影响,为明确弓形虫损害神经系统作用机制提供依据。1材料与方法1.1动物及分组选24只SD清洁级雄性大鼠(鼠龄4周)随机分为研究组(12只)与对照组(12只)。研究组腹腔感染2×10~(10)个/L RH株弓形虫速殖子悬
Toxoplasmosis is a zoonotic disease, affected by environmental pollution and lifestyle and other factors, the incidence in recent years showed a continuous upward trend. Therefore, this study explored the effect of Toxoplasma gondii infection on neurofilament mRNA expression and cellular immunity in rat brain tissue, and provided evidence for elucidating the mechanism of Toxoplasma gondii damaging the nervous system. 1 Materials and methods 1.1 Animals and groups 24 SD clean male rats (4 weeks old) were randomly divided into the study group (12) and the control group (12). The study group was intraperitoneally infected with 2 × 10 ~ (10) / L RH Toxoplasma gondii suspension