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目的:探讨阿托伐他汀对高脂血症性脂肪性肝炎大鼠的作用。方法:40只SD大鼠持续10周高脂饮食后随机分为2组:模型组(n=20)和阿托伐他汀组(n=20)均恢复正常饮食。同时给予阿托伐他汀(4 mg/kg·d-1)。另设20只普通饮食大鼠作正常对照。4周后处死,分别测定血清肝功能、甘油三酯(TG)、胆固醇(TC)、游离脂肪酸(FFA)、血浆脂蛋白脂酶(LPL)、肝脂酶(HL),血清及肝组织丙二醛(MDA)、肿瘤坏死因子-α(TNF-α),观察肝脏病理变化。结果:与对照组比较,模型组血脂、ALT、AST、血清及肝组织MDA、TNF-α明显升高,血浆LPL、HL明显下降,病理学检查示明显脂肪性肝炎;与模型组比较,阿托伐他汀组血脂紊乱明显改善,血清ALT、AST、血清及肝组织MDA明显降低,血浆LPI、HL明显升高,病理学检查接近正常,但TNF-α下降不明显。结论:阿托伐他汀可通过减轻脂质过氧化促进肥胖高脂血症性脂肪肝性肝炎的痊愈。
Objective: To investigate the effect of atorvastatin on hyperlipidemic steatohepatitis in rats. Methods: Forty SD rats were randomly divided into two groups after 10 weeks of high-fat diet: model group (n = 20) and atorvastatin group (n = 20) returned to normal diet. Atorvastatin (4 mg / kg · d-1) was also given. Another 20 normal diet rats for normal control. Four weeks later, the mice were sacrificed and their serum levels of hepatic function, triglyceride (TG), cholesterol (TC), free fatty acid (FFA), plasma lipoprotein lipase (LPL), hepatic lipase (HL) Dialdehyde (MDA) and tumor necrosis factor-α (TNF-α) were measured to observe the pathological changes of the liver. Results: Compared with the control group, the levels of serum lipids, ALT and AST, the levels of serum MDA and TNF-α in serum and liver tissue were significantly increased, while the levels of plasma LPL and HL were significantly decreased in the model group. The pathological examination revealed steatohepatitis. Compared with the model group, Serum levels of ALT, AST, serum and liver MDA were significantly lower in the atorvastatin group, LPI and HL were significantly increased, and pathological examination was close to normal, but TNF-αdecreased insignificantly. Conclusion: Atorvastatin can promote the recovery of obese hyperlipidemic steatohepatitis by reducing lipid peroxidation.