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目的：研究芳烃羟化酶（ＡＨＨ）与肺癌的关系。方法：采用ＡＨＨ直接测定法检查了肺癌患者４０例、其它癌症患者３２例及健康人４５例血液淋巴细胞中ＡＨＨ的诱导力。结果：１）肺癌组与健康对照组及肿瘤对照组之间构成比均无显著性差异（Ｐ＞０．０５，χ２检验）。２）肺鳞癌组与健康对照组高及低诱导力者之间构成比有显著性差异（Ｐ＜０．０５）；而中、低诱导力者之间构成比无显著性差异（Ｐ＞０．０５）。３）肺腺癌组及其它类型肺癌组与健康对照组之间构成比均无显著性差异（Ｐ＞０．０５）。４）高ＡＨＨ诱导力发生肺癌的相对危险性是低ＡＨＨ诱导力者的６倍。结论：ＡＨＨ的诱导力与肺癌，主要是肺鳞癌有关。作者认为，正常人群中的ＡＨＨ高诱导力者应成为重点预防对象。
Objective: To study the relationship between aromatic hydroxylase (AHH) and lung cancer. METHODS: The AHH-inducing ability of lymphocytes in 40 patients with lung cancer, 32 with other cancers, and 45 healthy individuals was examined using AHH direct assay. Results: 1) There was no significant difference in the composition ratio between lung cancer group and healthy control group and tumor control group (P>0.05, χ2 test). 2) There was a significant difference in the ratio of constituents between the lung squamous cell carcinoma group and the healthy control group (P < 0.05), but there was no significant difference in the composition ratio between the medium and low induction forces (P> 0.05). 3) There was no significant difference in the constitution ratio between lung adenocarcinoma group and other types of lung cancer group and healthy control group (P>0.05). 4) The relative risk of lung cancer with high AHH-inducing power is 6 times that of patients with low AHH-inducing force. Conclusion: The induction of AHH is associated with lung cancer, which is mainly related to lung squamous cell carcinoma. The authors believe that the high induction of AHH in the normal population should be the focus of prevention.