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目的 :探讨 CD56在急性白血病中的表达及其临床意义。方法 :就近 2年来应用流式细胞仪检测了CD56的 92例急性白血患者中发现的 CD56阳性病例 ,分析细胞形态学、免疫表型和临床特点。结果 :92例急性白血病中 15例 (16 .3% )表达 CD56,其中 1例急性前髓系 /NK细胞白血病 (Myeloid/NK cell precursor acute leukem ia) ,1例原始 NK细胞白血病 (Blastic NK cell leukemia) ,1例 NK样 T细胞淋巴瘤 /白血病 (NK- like T- cell lymphoma/leukemia) ,12例急性髓细胞白血病伴 NK细胞抗原表达或急性髓系 /NK细胞白血病。结论 :伴 CD56阳性急性白血病 ,其细胞形态学、免疫表型及临床表现各有特点 ,见于 M2 、M5、L2 ,髓外浸润多见 ,多预后不良。
Objective: To investigate the expression of CD56 in acute leukemia and its clinical significance. Methods : CD56 positive cases detected in 92 acute white blood patients with CD56 were detected by flow cytometry in the past 2 years. Cell morphology, immunophenotype and clinical features were analyzed. RESULTS: Of the 92 acute leukemias, 15 (16. 3%) expressed CD56, of which 1 was acute myeloid/NK cell precursor acute leukemia and 1 was primitive NK cell leukemia (Blastic NK cell). Leukemia), 1 case of NK-like T-cell lymphoma/leukemia, 12 cases of acute myeloid leukemia with NK cell antigen expression or acute myeloid/NK cell leukemia. Conclusion : With CD56 positive acute leukemia, its cell morphology, immunophenotype and clinical manifestations have their own characteristics. They are found in M2, M5, and L2. Extramedullary infiltration is more common and many have poor prognosis.