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目的探讨应用氩离子凝固术(APC)治疗胃黏膜脱垂症的疗效及安全性,并与微波治疗胃黏膜脱垂症的效果进行比较研究。方法选择2008年12月至2010年10月经胃镜检查确诊的140例胃黏膜脱垂症患者,按治疗方式随机分为两组:APC组69例,微波治疗组71例。观察比较两组患者的有效率、并发症、治疗疗程及费用。结果 (1)APC组和微波治疗组治疗1个月后症状缓解显效率分别为89.8%、83.1%,差异无显著性(P>0.05)。(2)1个月后胃镜复查病变消失率APC组和微波治疗组分别为93.8%、84.5%,差异有显著性(P<0.05)。(3)APC组治疗期间有7例出现轻度的并发症,给予对症处理后消失;微波治疗组有5例出现浅表溃疡,4例出现上消化道出血,对症治疗后痊愈。(4)两组患者住院时间比较无统计学差异(P>0.05),微波治疗组住院费用高于APC组(P<0.05)。结论氩离子凝固术治疗胃黏膜脱垂症效果明显,副作用小,值得临床推广应用。
Objective To investigate the efficacy and safety of argon plasma coagulation (APC) in the treatment of gastric mucosal prolapse and to compare the effects of microwave treatment of gastric mucosal prolapse. Methods 140 cases of gastric mucosal prolapse diagnosed by gastroscopy from December 2008 to October 2010 were randomly divided into two groups according to the treatment: 69 cases in APC group and 71 cases in microwave group. Observed and compared the efficiency of two groups of patients, complications, treatment and cost. Results (1) The effective rates of symptom relief in APC group and microwave treatment group after one month treatment were 89.8% and 83.1% respectively, with no significant difference (P> 0.05). (2) The disappearance rate of gastroscopy after 1 month was 93.8% and 84.5% respectively in APC group and microwave treatment group, the difference was significant (P <0.05). (3) In the APC group, 7 cases showed mild complication during symptomatic treatment and disappeared after giving symptomatic treatment. Five cases of microwave treatment group had superficial ulceration, 4 cases of upper gastrointestinal bleeding, cured after symptomatic treatment. (4) There was no significant difference in hospitalization time between the two groups (P> 0.05). The cost of hospitalization in microwave treatment group was higher than that in APC group (P <0.05). Conclusion Argon coagulation is effective in treatment of gastric mucosal prolapse and its side effects are small and worthy of clinical application.