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本文研究了不同孕期的正常孕妇81例(包括产后)及妊高征20例患者的尿中微量蛋白的变化。结果发现:妊高征患者与正常不同孕期的孕妇相比、IgG、IgA、白蛋白的排出明显增加(P<0.05~0.001),而IgM无差异。产后与晚期孕妇相比,IgM明显减少(P<0.05);而正常不同孕期的孕妇尿中各项蛋白的排出,虽随孕周的增加而增多,但无显著意义。妊高征患者尿蛋白的排出与病情严重程度有关。其中妊高征患者的平均动脉压(MAP)与尿中白蛋白、IgG的排出呈正相关。作者认为,轻、中度妊高征患者的肾小球滤过功能尚属于可逆性改变。对于妊高征患者,积极控制血压,防止肾脏由功能性发展为器质性改变是十分重要的。
This article studies the changes of urinary microalbuminuria in 81 pregnant women (including postpartum) and 20 cases of pregnancy induced hypertension (PIH) in different stages of pregnancy. The results showed that compared with pregnant women with different pregnancy stages, the levels of IgG, IgA and albumin in PIH patients increased significantly (P <0.05-0.001), but there was no difference in IgM. IgM was significantly lower in postnatal and late pregnant women than in late pregnant women (P <0.05). However, urinary protein excretion in pregnant women at different stages of pregnancy increased with gestational age but no significant difference. Patients with PIH urinary protein excretion and severity of the disease. The mean arterial pressure (MAP) in patients with PIH was positively correlated with urinary albumin and IgG excretion. The authors believe that glomerular filtration function in patients with mild and moderate pregnancy-induced hypertension is still a reversible change. For patients with PIH, it is very important to actively control blood pressure and prevent the kidney from developing functional changes into functional changes.