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目的:观察御寒暖胃膏对胃癌前病变大鼠胃黏膜的影响。方法:将50只SD大鼠随机分为正常组、模型组、御寒暖胃膏贴敷胃经穴组、御寒暖胃膏贴敷对照点组和药物对照组,每组各10只。采用综合干预方法复制慢性萎缩性胃炎癌前病变大鼠模型,正常组喂饲标准饲料,不予任何处理。模型组自第21周开始,每天捆绑1 h,并予胶布贴敷腹部及双下肢,每只每天按0.001 m L·g~(-1)的剂量经口灌服纯净水。御寒暖胃膏贴敷胃经穴组、对照点组自第21周开始,每天将各组大鼠捆缚于鼠板,将膏药涂于所选部位上,每日1 h。每只每天按0.001 m L·g-1的剂量经口灌服纯净水。药物对照组给予维酶素溶液,按21.6 mg·kg~(-1)的药量给药,每日1次,每天捆绑1 h,并予胶布贴敷腹部皮肤及双下肢。肉眼下观察大鼠胃黏膜损伤指数,光镜下观察胃黏膜组织的病理变化,彩色多普勒观察胃黏膜的血流量。结果:与模型组比较,御寒暖胃膏贴敷胃经穴组和药物对照组大鼠胃黏膜损伤指数值均显著降低,差异具有统计学意义(P<0.005);胃黏膜组织的病理损伤得到明显的修复、胃黏膜血流量均显著升高,差异具有统计学意义(P<0.005)。御寒暖胃膏贴敷对照点组大鼠胃黏膜损伤指数值未见明显降低,差异无统计学意义(P>0.005);胃黏膜组织的病理损伤未得到明显修复、胃黏膜血流量未见显著升高,差异无统计学意义(P>0.005)。结论:御寒暖胃膏贴敷胃经穴可以促进慢性萎缩性胃炎癌前病变大鼠胃黏膜损伤的修复,增加胃黏膜的血流量,并且存在经脉—脏腑特异相关性。
Objective: To observe the effect of warm cold warming stomach paste on precancerous lesions of gastric mucosa. Methods: Fifty Sprague-Dawley rats were randomly divided into normal group, model group, warm cold stomach paste applied to the gastric meridian acupoints group, warm cold stomach paste applied control point group and drug control group, 10 in each group. The rat model of precancerous lesions of chronic atrophic gastritis was replicated by comprehensive intervention. The normal group was fed with standard feed without any treatment. The model group was lasted 1 week from the 21st week, and the abdomen and both lower extremities were affixed with adhesive tape. Each day, the model group was orally dosed with pure water at a dosage of 0.001 m L · g -1. Warm and stomach paste applied to gastric meridian group, control point group from the 21st week, the rats were tied to the rat plate every day, the plaster applied to the selected site, 1 h daily. Every day by 0.001 m L · g-1 dose of oral irrigation with pure water. Drug control group was treated with the enzyme solution, according to a dose of 21.6 mg · kg ~ (-1) once a day, tied 1 h per day, and the tape affixed to the abdominal skin and lower extremities. The gastric mucosal injury index was observed under the naked eye, the pathological changes of gastric mucosa were observed under light microscope, and the gastric mucosal blood flow was observed by color Doppler. Results: Compared with the model group, the mean value of gastric mucosal lesion index of the Weiniweiwei ointment group and the drug control group were significantly decreased (P <0.005), and the pathological damage of the gastric mucosa tissue was obtained Obvious repair, gastric mucosal blood flow were significantly increased, the difference was statistically significant (P <0.005). There was no significant difference in the index of gastric mucosal injury between the control group and the control group (P> 0.005). The pathological changes of gastric mucosa were not significantly repaired and the gastric mucosal blood flow was not significant Increased, the difference was not statistically significant (P> 0.005). Conclusion: Preventing and Treating Gastric Mucosa Injury in Chronic Atrophic Gastritis Precancerous Lesion by Applying Warming Wei and Weiping on Stomach Meridian, Increasing Gastric Mucosal Blood Flow and Presence of Specific Correlation of Meridians and Viscera.