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目的:探讨超声造影(CEUS)对肝硬化合并肝内微小结节的诊断价值.方法:纳入2016年5月—2017年5月行 CEUS检查的肝硬化合并微小结节患者80例,依据病理结果分为小肝癌组 (恶性结节,35例)、良性病灶组(良性结节,45例),分析其影像学特点、三期增强模式及Peak％、SI、开始增强时间、TTP、MTT,评估CEUS诊断肝硬化合并肝内微小结节的效能.结果: CEUS显示小肝癌肝、肝硬化微小结节均有不同影像特点:两组三期增强模式比较差异有统计学意义、(P＜0.01);小肝癌组Peak％、SI高于良性病灶组,小肝癌组开始增强时间、TTP、MMT较良性病灶组缩短(P＜0.05) : CEUS诊断肝硬化合并肝内微小结节的灵敏度、特异度、准确度分别为 88.89％、77.14％、83.75％ (P＜0.05).结论:CEUS对肝硬化合并肝内微小结节有较高诊断价值,可完整、动态观察增强时相表现,与小肝癌进行鉴别.“,”Objective: To explore the diagnostic value of contrast-enhanced ultrasonography (CEUS) in the treatment of liver cirrhosis complicated with intrahepatic small nodules. Methods: 80 cases of patients with liver cirrhosis complicated with small nodules from May 2016 to May 2017 treated with CEUS were enrolled and divided into the small liver carcinoma group ( malignant nodules, n=35 ) and the benign lesions group ( benign nodules, n=45 ) according to the pathological results. The imaging features, three- phase enhanced mode and Peak％, SI, first enhanced slope time, TTP, and MTT of two groups were analyzed, and the efficiency of CEUS in diagnosis of liver cirrhosis complicated with intrahepatic small nodules were assessed. Results: CEUS images showed there were different imaging features in small liver carcinoma and the small nodules in liver cirrhosis. There were statistically significant differences in the three-phase enhancement mode between the two groups (P＜0.01 ). The levels of Peak％ and SI in the small liver carcinoma group were higher than those in the benign lesions group, and the first enhanced time, TTP and MMT were shortened compared with those in the benign lesions group (P＜0.05).The sensitivity, specificity and accuracy of CEUS in the diagnosis of liver cirrhosis complicated with intrahepatic small nodules were 88.89％, 77.14％ and 83.75％ (P＜0.05). Conclusion: CEUS has a high diagnostic value for liver cirrhosis complicated with intrahepatic small nodules. It can be used to observe the enhancement and can be used to identify that from small liver carcinoma.