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手性相转移催化是不对称催化领域的重要分支之一,扮演着越来越重要的角色。本论文综述了几类新型手性季鏻盐催化剂的设计合成,及其在催化不对称Henry反应、不对称氢磷酰化反应、不对称烷基化反应、不对称Michael加成反应、不对称Mannich反应、不对称aldol反应、不对称质子化反应及不对称胺化反应中的催化活性和对映选择性,重点介绍了不同催化剂和反应底物之间立体效应和电子效应的影响,并对手性季鏻盐催化剂的发展进行了展望。
Chiral phase transfer catalysis is one of the important branches in the field of asymmetric catalysis, playing an increasingly important role. In this paper, the synthesis and synthesis of several novel chiral quaternary phosphonium salts are summarized, as well as their applications in asymmetric Henry reaction, asymmetric hydrogen phosphorylation, asymmetric alkylation, asymmetric Michael addition, asymmetric Mannich reaction, asymmetric aldol reaction, asymmetric protonation reaction and asymmetric amination reaction in the catalytic activity and enantioselectivity, focusing on the different catalysts and reaction substrate between the stereoscopic effect and the effect of electronic effects, and the opponent The development of quaternary phosphonium salt catalysts is prospected.