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目的探讨双酚A(BPA)暴露对职业女工性激素的影响。方法采用病例-对照研究方法,选取51名BPA暴露至少一年的女工作为BPA暴露组,104名BPA未暴露的女工作为对照组,收集两组人群的一般人口学特征、BPA暴露情况、月经情况等,采集清晨空腹静脉血,用放射免疫分析法检测血清中卵泡刺激素(FSH)、催乳素(PRL)、雌二醇(E2)、孕酮(P)、促黄体激素(LH)水平。结果 BPA暴露组PRL的水平显著高于对照组(t=2.127,P=0.047)。暴露组PRL的异常比例显著高于对照组(χ2=4.924,P=0.026)。大于30岁年龄组中,暴露组PRL(χ2=5.131,P=0.023)和孕酮(χ2=4.665,P=0.031)的异常比例均显著高于对照组。在未服用维生素的人中,暴露组PRL的异常比例显著高于对照组(χ2=6.541,P=0.011)。暴露年限小于5年组孕酮的异常比例显著高于暴露年限大于5年组(χ2=3.938,P=0.047)。经多因素分析发现,BPA暴露是影响女工血清中PRL的独立危险因素(OR=2.623,P=0.030)。未发现BPA对血清中FSH、E2、LH的影响。结论 BPA职业暴露女工血清PRL水平升高,孕酮水平受到BPA暴露的影响。在调整了年龄、暴露年限等可能的混杂因素后,发现BPA暴露是影响职业女工血清PRL水平的独立危险因素。
Objective To investigate the effects of BPA exposure on sex hormone in working women. Methods A case-control study was conducted in which 51 female workers who were exposed to BPA for at least one year were selected as the BPA exposure group and 104 female unexposed BPA workers as control group. The demographic characteristics, BPA exposure, Menstrual flow and so on. Fasting venous blood was collected early in the morning. Serum follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2), progesterone (P), luteinizing hormone (LH) Level. Results The level of PRL in BPA exposed group was significantly higher than that in control group (t = 2.127, P = 0.047). The abnormal proportion of PRL in exposed group was significantly higher than that in control group (χ2 = 4.924, P = 0.026). In the age group of more than 30 years, the abnormal proportion of PRL (χ2 = 5.131, P = 0.023) and progesterone (χ2 = 4.665, P = 0.031) in the exposed group were significantly higher than those in the control group. Among those who did not take vitamins, the abnormal proportion of PRL in the exposed group was significantly higher than that in the control group (χ2 = 6.541, P = 0.011). The abnormal proportion of progesterone with exposure life less than 5 years was significantly higher than that with exposure longer than 5 years (χ2 = 3.938, P = 0.047). Multivariate analysis revealed that BPA exposure was an independent risk factor for PRL in female workers (OR = 2.623, P = 0.030). No effect of BPA on serum FSH, E2 and LH was found. Conclusion The level of PRL in female workers with BPA occupational exposure is elevated, and the level of progesterone is influenced by BPA exposure. After adjusting for possible confounding factors such as age, duration of exposure, and the like, BPA exposure was found to be an independent risk factor for PRL levels in professional women workers.