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目的:探讨联合治疗变异型心绞痛的临床治疗效果。方法:对18例行选择性冠状动脉造影术。药物联合治疗上给予硝酸类酯药物口服;地尔硫缓释片每次90 mg,1~2次/d,肠溶阿司匹林每晚100 mg,其中5例加用哌唑嗪。结果:21例患者经治疗都有了不同程度的改善,其中18例经冠状动脉造影证实有12例为至少1支主要冠脉显著的固定性近段冠状动脉狭窄。结论:变异型心绞痛的发病机制主要与内皮细胞损伤及动脉粥样硬化有关,其治疗的重点在于早期诊断,早期治疗处理,防止其发展与恶化。
Objective: To investigate the clinical effect of combined treatment of variant angina pectoris. Methods: 18 cases underwent selective coronary angiography. Drugs combined treatment of oral administration of nitric ester drugs; Diltiazem sustained-release tablets each 90 mg, 1 to 2 times / d, enteric-coated aspirin 100 mg nightly, of which 5 cases plus prazosin. RESULTS: Twenty-one patients had different degrees of improvement after treatment. Eighteen of the 18 patients confirmed by coronary angiography showed at least one major coronary artery with significant proximal coronary stenosis. Conclusion: The pathogenesis of variant angina pectoris is mainly related to endothelial cell injury and atherosclerosis. The treatment of variant angina pectoris is focused on early diagnosis and early treatment to prevent its development and deterioration.