[目的]研究加加宁口服液对高脂血症小鼠血脂和相关脏器的干预效果。[方法]模型组昆明小鼠喂饲高脂饲料,实验组昆明小鼠喂饲高脂饲料同时以加加宁口服液(原液及3倍稀释液)灌胃,4周后检测血清TC、TG、HDL-C和LDL-C含量,测定脏器系数,观察肝脏及胰腺组织结构。[结果]加加宁口服液可降低高脂血症小鼠TC、TG和LDL-C含量;恢复HDL-C含量、肝脏系数及脂肪系数;减轻高脂饮食对肝脏和胰腺的损害。[结论]加加宁口服液有减轻高脂饮食对小鼠造成的脂肪代谢紊乱及脏器损害的作用。 [Objective] The research aimed to study the effect of Jiajining Oral Liquid on the blood lipid and related organs of hyperlipidemic mice. [Method] Kunming mice were fed with high-fat diet. Kunming mice were fed with high-fat diet and gavarnine oral solution (original solution and 3-fold dilution) at the same time. After 4 weeks, serum TC, TG , HDL-C and LDL-C levels were measured, the organ coefficient was measured and the structure of liver and pancreas were observed. [Result] Jiajining oral solution can reduce the levels of TC, TG and LDL-C in hyperlipidemic mice; restore HDL-C content, liver coefficient and fat coefficient; and alleviate the damage to the liver and pancreas of high-fat diet. [Conclusion] Jiajining oral liquid can alleviate the dyslipidemia and organ damage caused by high-fat diet in mice.