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表皮生长因子受体(epidermal growth factorreceptor,EGFR)家族,亦称 erbB 受体,含4个成员即 EGFR(erbB-1、HER1)、erbB-2(HER2/neu)、erbB-3(HER3)和 erbB-4(HER4),均属于Ⅰ型酪氨酸激酶受体(typel-receptor tyrosine kinase,TITK)。这些受体是单个氨基酸链蛋白。每一受体含3个区域(domain)即细胞外区、疏水跨膜区和细胞内区。细胞外区为受体及其相应的配体或配体样物质结合处。受体与配体或配体样物质结合后形成同种或异种二聚体。二聚体跨膜进入细胞内区、激活酪氨酸激酶、底物转磷酸化(transphosphorylation)、启动一
The family of epidermal growth factor receptor (EGFR), also known as erbB receptor, contains four members, EGFR (erbB-1, HER1), erbB-2 (HER2 / neu), erbB-3 erbB-4 (HER4), belong to the type I tyrosine kinase receptor (typel-receptor tyrosine kinase, TITK). These receptors are single amino acid chain proteins. Each receptor contains three domains, the extracellular domain, the hydrophobic transmembrane domain, and the intracellular domain. The extracellular region is the receptor and its corresponding ligand or ligand-like substance junction. Receptors form ligands or heterodimers upon binding to a ligand or ligand-like material. The dimer transmembrane enters the intracellular domain, activates tyrosine kinases, transphosphorylation of substrates, initiates a