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目的:探讨心理应激对大鼠胃排空及胃泌素(GAS)、胃动素(MOT)的影响及中药升降方的干预作用。方法:Wistar大鼠随机分成空白对照组、心理应激组、升降方高、低剂量(11.0,5.5 g.kg-1)加心理应激组。心理应激组给予复合应激,升降方高、低剂量组在心理应激组基础上分别给予升降方高、低剂量灌胃给药,15 d后测定各组大鼠胃排空及GAS,MOT的含量。结果:15 d后心理应激组大鼠的体重、胃排空率,GAS,MOT与空白对照组比较均明显下降(P<0.01或P<0.05);升降方高、低剂量(11.0,5.5 g.kg-1)加心理应激组的体重、胃排空率,GAS,MOT含量与心理应激组比较均明显升高(P<0.05)。结论:心理应激对大鼠胃排空有明显抑制作用,引起实验大鼠GAS和MOT水平下降,升降方可拮抗心理应激对大鼠胃排空的抑制,升高GAS和MOT水平。
Objective: To investigate the effects of psychological stress on gastric emptying and gastric motility (GAS) and motilin (MOT) in rats and the intervention effect of Chinese herbs. Methods: Wistar rats were randomly divided into blank control group, psychological stress group, high and low lift side, low dose (11.0,5.5 g.kg-1) plus psychological stress group. The rats in the psychological stress group were given compound stress, and the rats in the low-dose group were given high and low doses of gavage on the basis of the psychological stress group. After 15 days, the gastric emptying and GAS, MOT content. Results: The body weight, gastric emptying rate, GAS, MOT of the psychological stress group were significantly decreased compared with the control group (P <0.01 or P <0.05) g.kg-1) plus psychological stress group, body weight, gastric emptying rate, GAS, MOT content were significantly higher than the psychological stress group (P <0.05). CONCLUSION: Psychological stress can significantly inhibit the gastric emptying in rats and cause the levels of GAS and MOT in experimental rats to decrease. Ascending and descending can antagonize the inhibitory effect of psychological stress on gastric emptying in rats and increase the levels of GAS and MOT.