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目的 :通过应用低分子肝素及普通肝素对糖尿病肾衰进行血透 ,了解低分子肝素对糖尿病肾衰血脂代谢的影响。方法 :将 32例糖尿病肾衰患者随机分成实验组 (LMWH组 ,n =16 )和对照组 (UFH组 ,n =16 ) ,LMWH组和UFH组分别使用低分子肝素和普通肝素进行血液透析一年 ,观察两组患者血脂变化情况。结果 :实验过程中LMWH组患者血清胆固醇 (CH)及甘油三酯 (TG)水平明显下降 ,高密度脂蛋白 (HDL)、载脂蛋白A(ApoA1)明显升高 ,均有明显差异 ,具统计学意义。UFH组中CHOL无明显变化 ,TG及LDL明显升高 ,HDL明显降低 ,均有统计学差异。同时对LMWH组和UFH组之间进行比较显示 ,在透析开始时CH、TG、HDL、LDL、ApoA1及ApoB均无统计学差异 ;透析一年后LMWH组与UFH组相比 ,CH、TG、LDL进一步下降 ,HDL、ApoA1明显上升 ,而且具有统计学意义。结论 :LMWH透析可以改善糖尿病肾衰患者的血脂代谢。
Objective: To evaluate the effect of low molecular weight heparin on the blood lipid metabolism of diabetic renal failure by applying low molecular weight heparin and unfractionated heparin to hemodialysis of diabetic renal failure. Methods: 32 patients with diabetic renal failure were randomly divided into experimental group (LMWH group, n = 16) and control group (UFH group, n = 16). LMWH group and UFH group were treated with low molecular weight heparin and unfractionated heparin Year, observed changes in two groups of patients with blood lipids. Results: The levels of serum cholesterol (CH) and triglyceride (TG) in patients with LMWH decreased significantly during the experiment, and the levels of HDL and ApoA1 were significantly increased Significance of learning. CHOL in UFH group showed no significant change, TG and LDL increased significantly, HDL decreased significantly, both with statistical significance. At the same time, comparison between LMWH group and UFH group showed no significant difference in CH, TG, HDL, LDL, ApoA1 and ApoB at the beginning of dialysis. One year after dialysis, compared with UFH group, CH, TG, LDL further decline, HDL, ApoA1 increased significantly, and with statistical significance. Conclusion: LMWH dialysis can improve blood lipid metabolism in patients with diabetic renal failure.