曼氏血吸虫的致病机制主要是由于虫卵沉积于宿主肝脏引起弥漫性肉芽肿及随之产生的纤维化。虫卵释放的可溶性蛋白和糖蛋白参与肉芽肿的形成等病理过程,其中酶的作用更显重要。以往的研究提示,诱导针对某种酶(例如谷胱甘肽转移酶)的免疫应答能够减轻虫卵引起的病理反应。因此,有必要对虫卵中各成份(尤其是酶)的特性进行研究。 The pathogenesis of Schistosoma mansoni is mainly due to egg deposition in the host liver caused by diffuse granulomatous and subsequent fibrosis. Egg release of soluble proteins and glycoproteins involved in the formation of granulomas and other pathological processes, of which the role of enzymes is more important. Previous studies have suggested that inducing an immune response against a certain enzyme, such as glutathione transferase, can reduce the pathogenic response of eggs. Therefore, it is necessary to study the characteristics of each component of eggs (especially enzymes).