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目的研究妊娠哺乳期乳腺癌在诊断和治疗方面的特殊性。方法选择2000-01-2009-12间的妊娠哺乳期乳腺癌24例,发病年龄29~38岁,平均年龄34岁,肿块2.5~11 cm,均为无痛性。按WHO分期标准,其中Ⅱa期2例,Ⅱb期5例,Ⅲa期7例,Ⅲb期9例,Ⅲc期1例。病理类型:浸润性导管癌12例,浸润性小叶癌8例,炎性乳腺癌3例,单纯癌1例。24例患者均在终止妊娠及哺乳后行综合治疗,追踪24例患者9 a内情况。结果 5 a生存率分别为62.5%,5 a复发及转移率为75.0%。结论妊娠哺乳期乳腺癌发现晚,病期晚预后差,肿瘤恶性程度高,5 a生存率较非妊娠哺乳期乳腺癌低。
Objective To study the specificity of diagnosis and treatment of breast cancer during pregnancy and lactation. Methods Twenty-four pregnant women with breast-feeding during pregnancy between January 2000 and December 2009 were selected. The age of onset was 29 to 38 years, with a mean age of 34 years and a mass of 2.5 to 11 cm. All of them were painless. According to WHO staging standards, including 2a Ⅱa, Ⅱb 5 cases, Ⅲa 7 cases, Ⅲb 9 cases, Ⅲc 1 case. Pathological types: invasive ductal carcinoma in 12 cases, invasive lobular carcinoma in 8 cases, inflammatory breast cancer in 3 cases, simple carcinoma in 1 case. Twenty-four patients underwent comprehensive treatment after termination of pregnancy and lactation, and the follow-up of 24 patients within 9 years was performed. Results The 5-year survival rates were 62.5% and 5-year recurrence and metastasis rates were 75.0%. Conclusion Breast cancer in late stage of pregnancy is found late, late stage of disease has poor prognosis, high degree of malignancy, 5-year survival rate than non-pregnant breast-feeding breast cancer is low.