我们曾以乙酰水杨酸为起始原料,经氯化、缩合、水解制得本品。由于该法合成路线较长,所用有机溶剂的种类较多,用量亦较大。因此,我们又研究了将水杨酸与对乙氧基苯胺直接缩合方法,用“均匀没计”法考察了它的主要影响因素,经多元回归分析,从建立的回归方程的各因素考察范围内优选出较佳工艺条件,收率达42.6%。 We have acetylsalicylic acid as the starting material, the chlorination, condensation, hydrolysis of the goods. Due to the long route of synthesis, the types of organic solvents used are more and the dosage is also larger. Therefore, we also studied the direct condensation of salicylic acid and p-ethoxyaniline method, using the “even did not count” method to examine its main influencing factors, by multiple regression analysis, from the establishment of the regression equation of the factors investigated Optimized within the better process conditions, the yield was 42.6%.