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目的比较不同种类肝癌化疗药物与碘油混合配制成混悬液在原发性肝癌(PLC)化疗栓塞(TACE)治疗中的疗效。方法分别将顺铂、氟脲苷、表柔吡星3种不同种类的肝癌化疗药物与碘化油混合配制成混悬液,对原发性肝癌血管进行栓塞治疗,通过观察术后患者肿瘤最大直径的变化对化疗栓塞治疗的效果进行分析。结果原发性肝癌超选择性化疗栓塞术后,各组肿瘤均有不同程度缩小,且差异有统计学意义(P<0.005)。使用表柔吡星与碘油配制成的化疗药物碘油混悬液栓塞治疗组肿瘤缩小程度较顺铂和氟脲苷碘油混悬液组缩小程度明显,差异有统计学意义(P<0.005)。结论碘油与表柔吡星配置成的混悬液栓塞效果优于顺铂和氟脲苷碘油混悬液。
Objective To compare the curative effects of different kinds of hepatocarcinoma chemotherapy drugs and lipiodol formulated as suspensions on the treatment of primary hepatocellular carcinoma (PLC) with chemoembolization (TACE). Methods Three different kinds of hepatocarcinoma chemotherapeutic drugs such as cisplatin, fluoxetine and epirubicin were mixed with iodized oil to prepare suspension. The embolization of the primary hepatic carcinoma was performed. The maximal tumor size The effect of chemoembolization on the change of diameter was analyzed. Results After selective chemoembolization of primary hepatocellular carcinoma, the tumors in all groups shrank to varying degrees, and the difference was statistically significant (P <0.005). Compared with cisplatin and fluorouridine glycoside lipiodol suspension group, the extent of tumor shrinkage in the treatment group with lipiodol suspension embolization was significantly reduced (P <0.005 ). Conclusions Lipiodol and epirubicin are superior to embolization of cisplatin and fluriduridine lipiodol suspension in suspension.