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蛋白激酶 Ｃ（Ｐｒｏｔｅｉｎ Ｋｉｎａｓｅ Ｃ，ＰＫＣ）是一类由多种同工酶组成的丝氨酸／苏氨酸蛋白激酶家族。ＰＫＣ处于磷脂酰肌醇代谢的中心环节，与细胞的增殖、分化、神经传导、基因表达调节及肿瘤发生等病理生理过程有着密切的联系。近年来研究表明，ＰＫＣ在缺血性脑损害发病机制中起着较为重要的作用。本文拟就ＰＫＣ同工酶概况及与脑缺血关系的研究现状作一综述。
Protein Kinase C (PKC) is a family of serine / threonine protein kinases that consist of multiple isozymes. PKC is at the center of phosphatidylinositol metabolism, which is closely related to the pathophysiological processes such as cell proliferation, differentiation, nerve conduction, gene expression regulation and tumorigenesis. In recent years, studies have shown that PKC plays an important role in the pathogenesis of ischemic brain damage. This article intends to overview the status of PKC isozymes and their relationship with cerebral ischemia.