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目的观察雷贝拉唑联合新络纳治疗老年性反流性食管炎的疗效及安全性。方法选择郸城县人民医院2012年6月至2014年12月收治的87例老年性反流性食管炎患者作为研究对象,随机数字表法分为观察组44例与对照组43例。对照组单独应用雷贝拉唑进行治疗,观察组在对照组基础上联用新络纳,比较两组症状总有效率、内镜总有效率与不良反应发生率。结果观察组症状与内镜治疗总有效率分别为90.9%、86.4%,均分别高于对照组的72.1%、67.4%,差异有统计学意义(P<0.05)。观察组、对照组不良反应发生率分别为9.1%、7.0%,差异未见统计学意义(P>0.05)。结论雷贝拉唑联合新络纳治疗老年性反流性食管炎可有效改善烧心与返酸症状,治疗有效率更高,安全可靠,具有较大借鉴、推广价值。
Objective To observe the efficacy and safety of rabeprazole combined with Xinoluona in the treatment of senile reflux esophagitis. Methods A total of 87 elderly patients with reflux esophagitis admitted to Dancheng People’s Hospital from June 2012 to December 2014 were selected as study subjects. The random number table was divided into observation group (44 cases) and control group (43 cases). The control group was treated with rabeprazole alone. The observation group was treated with neoadjuvant on the basis of the control group. The total effective rate of the symptoms, the total effective rate of endoscopy and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group and endoscopic treatment were 90.9% and 86.4%, respectively, which were significantly higher than that of the control group (72.1% and 67.4%, respectively) (P <0.05). The incidence of adverse reactions in the observation group and control group were 9.1% and 7.0%, respectively, with no significant difference (P> 0.05). Conclusion Rabeprazole combined with Xinluo Na for the treatment of senile reflux esophagitis can effectively improve the symptoms of heartburn and acid reflux. The treatment is more effective, safe and reliable, and has great reference and promotion value.