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五氯酚钠是我国血吸虫流行地区常用的杀灭血吸虫中间宿主钉螺的药物。为评价长期使用后对环境和人体健康的影响，在四川、江西、江苏和福建省的血吸虫病流行地区及对照区，在非用药期间（施用五氯酚后一个月以上）开展了五氯酚的环境污染、人体接触量及健康影响的研究。结果显示：用药区除空气外，其它环境介质（水、土壤、底泥、动植物）五氯酚含量均显著高于对照区，用药区食品、人群五氯酚的日摄取量及尿中五氯酚浓度也均显著高于对照区，表明已造成用药区环境五氯酚的污染和人体内的蓄积。健康检查和生化检查显示除用药区血胆碱酯酶活力较对照区有２２％～２８％的下降外，未见其它影响。文中还讨论了五氯酚中二口恶烷类和呋喃类有害杂质对健康影响的可能性。
Sodium pentachlorophenate is a commonly used drug to kill snail schistosomes in the endemic areas of schistosomiasis in our country. In order to evaluate the environmental and human health effects after long-term use, pentachlorophenol (PCP) was conducted during non-drug use (more than one month after pentachlorophenol application) in the endemic and control areas of schistosomiasis in Sichuan, Jiangxi, Jiangsu and Fujian Provinces Environmental pollution, human exposure and health effects. The results showed that the contents of pentachlorophenol in other environmental media (water, soil, sediments, animals and plants) were significantly higher than those in the control area except for the air in the medication area. The daily intakes of pentachlorophenol Chlorophenol concentrations were also significantly higher than the control area, indicating that the drug has caused environmental pollution caused by pentachlorophenol and human accumulation. Health examination and biochemical examination showed that there was no other effect except that the blood cholinesterase activity in the medication area was decreased by 22% -28% compared with the control area. The article also discussed the pentachlorophenol in two classes of noxanes and furans harmful impurities the possibility of health effects.