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目的:观察琼玉膏对人肝癌细胞移植裸鼠HBxAg表达的影响,分析其通过影响HBxAg表达防治原发性肝癌的机制。方法:建立人肝癌细胞移植裸鼠模型,观察琼玉膏预防及治疗对小鼠体质量、癌组织质量的影响,同时采用免疫组化法测定癌组织及肝脏中HBxAg的表达。结果:与模型组相比,琼玉膏预防及治疗后,裸鼠的体质量增长迅速,癌组织质量偏低,癌组织及肝脏HBxAg低表达。琼玉膏预防与环磷酰胺治疗的效果相近。结论:琼玉膏能减缓肿瘤的生长,并抑制HBxAg的表达,后者可能是其防治原发性肝癌的主要机制之一。
Objective: To observe the effect of Qiong Yuxiang on the expression of HBxAg in human hepatoma cells transplanted in nude mice, and to analyze its mechanism of preventing and treating primary hepatocellular carcinoma by affecting the expression of HBxAg. Methods: To establish the model of human hepatocellular carcinoma transplanted in nude mice and observe the effect of Qiong Yu Paste on prevention and treatment of mice body weight and the quality of cancer tissue. At the same time, the expression of HBxAg in cancer tissue and liver was detected by immunohistochemistry. Results: Compared with the model group, the body weight of nude mice grew rapidly after the prevention and treatment of Qiongyu Paste. The quality of cancer tissue was low, and the expression of HBxAg in cancer tissue and liver was low. Qiong Yu cream prevention and cyclophosphamide treatment effect is similar. Conclusion: Qiong Yu Pill can slow the growth of tumor and inhibit the expression of HBxAg, which may be one of the main mechanisms of prevention and treatment of primary liver cancer.