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目的:调查分析不同海拔梯度久居男性干部高尿酸血症的患病率及其相关因素。方法:海拔2 800m、3 400m、4 500m共693名体检男性干部。尿酸(UA)检测采用日立7020型全自动生化分析仪测定(尿酸酶法),HUA诊断标准为血清UA≥420μmol/L。结果:高尿酸血症患病率依海拔从低到高依次为28.88%(119/412)、50.37%(68/135)、69.86%(102/146),不同海拔组高尿酸血症患病率有差异(P<0.01);Perason相关与多元线性逐步回归分析:UA水平与海拔高度、高原红细胞增多症、超重、血液肌酐增高密切关联,并与HUA互相间有较高的相偕患病率。结论:在高原久居男性中有较高的HUA检出率,海拔高度、血红蛋白、体重指数、肌酐水平是HUA的危险因素。
Objective: To investigate the prevalence and related factors of hyperuricemia in male cadres at different altitudes. Methods: A total of 693 male cadres at 2 800 m, 3 400 m and 4 500 m above sea level were enrolled. Uric acid (UA) test using Hitachi 7020 automatic biochemical analyzer (uricase method), HUA diagnostic criteria for the serum UA ≥ 420μmol / L. Results: The prevalence of hyperuricemia was 28.88% (119/412), 50.37% (68/135) and 69.86% (102/146), respectively. The prevalence of hyperuricemia (P <0.01). Perason correlation and multivariate linear stepwise regression analysis: UA level was closely related to altitude, altitude polycythemia, overweight and blood creatinine, and had a higher relative phase with HUA rate. Conclusion: The prevalence of HUA, altitude, hemoglobin, body mass index and creatinine were the risk factors for HUA among men in high altitude.