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目的观察单侧迷路破坏术后前庭内侧核(medialvestibular nuclei,MVN)内I组代谢性谷氨酸受体亚型(group I metabotropic glutamate receptors,mGluR1)的表达变化。方法成年雄性Wistar大鼠28只,分为迷路破坏组(20只)和对照组(8只),前者破坏单侧迷路,对照组手术方式相同但保持迷路完好。单侧迷路破坏术后,通过免疫组织化学、原位杂交组织化学法检测不同存活时间(术后12h、36h、7d、30d)两组动物MVN内mGluR1的表达变化。结果单侧迷路破坏术后可诱导同侧MVN区I组代谢性谷氨酸受体亚型mGluR1减少,术后12h最少,术后36h开始增加,至术后7d和30d后和对照组差异无统计学意义;对侧和术侧的变化趋势相同。结论单侧迷路破坏术后可诱导MVN区I组代谢性谷氨酸受体亚型mGluR1减少。初级前庭传入或中枢前庭神经元的静息放电降低可能与I组代谢性谷氨酸受体亚型mGluR1减少有关,但其在前庭代偿中的作用尚有待研究。
Objective To investigate the expression of group I metabotropic glutamate receptors (mGluR1) in the medial vestibular nuclei (MVN) after unilateral labyrinthectomy. Methods Totally 28 adult male Wistar rats were divided into 2 groups: the lost group (n = 20) and the control group (n = 8). The former destroyed unilateral labyrinth and the control group operated in the same way but remained lost. After unilateral labyrinthine destruction, the expression of mGluR1 in MVN was detected by immunohistochemistry and in situ hybridization in two groups at different survival time (12h, 36h, 7d, 30d). Results After unilateral laminectomy, the metabotropic glutamate receptor subtype mGluR1 was decreased in ipsilateral MVN group, at least 12 hours after operation and 36 hours after operation. The differences were not found between the 7th and 30th postoperative days and the control group Statistical significance; contralateral and surgical changes in the same trend. Conclusion Unilateral labyrinthine injury can induce the decrease of metabotropic glutamate receptor subgroup mGluR1 in MVN area. The reduction of resting discharge in primary vestibular afferent or central vestibular neurons may be related to the reduction of mGluR1, a metabotropic glutamate receptor subgroup in group I, but its role in vestibular compensation remains to be studied.