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在职业生产和日常生活中,农药污染物可通过皮肤、呼吸、消化道等多种途径进入体内,损伤生殖器官和生精细胞功能,影响内分泌功能.引起生殖相关基因的异常表达,从而影响男(雄)性精子发生的正常进行,导致男性少精、弱精、精子畸形或无精子症.为探讨农药污染对生精细胞毒性的一般规律与内在机制.该文对农药污染与雄性生殖毒性之间的关系进行综述,为预防并干预有机农药的雄性生殖毒性,保障生殖健康等提供基础资料.“,”In the occupational production and the daily life, the pollutant of pesticides may enter our bodies through the skin-contact, the breath and the gastrointestinal absorption and so on. It may cause the reproductive organ and the spermatogenic cell damaged, abnormal endocrine function and the reproduction related genes expressed abnormally, resulting to abnormal spermatogenesis, which leads to oligospermia, asthenospermia, teratospormia and azoospermia, in order to look for a normal pattern and investigate the intrinsic mechanism of the eytotoxicity to the spermatogenic cell correlated with the pesticide pollution, it is necessary to review the relationship between the toxicity of pesticide pollutant and the abnormity of male spermatogenic cell, which will provide some basic information for preventing and controlling the reproductive toxicity of pesticides and ensuring the reproduction healthy of people.