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近年来研究显示,p16基因第1外显予5’CpG岛的高甲基化在多种肿瘤的发生发展中起重要作用,特别是在一些过去未发现有p16基因缺失与突变的肿瘤中也发现由p16基因甲基化而引起的基
In recent years, studies have shown that the first hypermethylation of 5’CpG island of p16 gene plays an important role in the occurrence and development of many tumors, especially in some tumors that have not been found with p16 gene deletion and mutation in the past. p16 gene methylation caused by the base