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DC-SIGN是具有糖结合域的II型跨膜蛋白,普遍存在于巨噬细胞、树突状细胞等免疫细胞表面。DC-SIGN在感染、炎症、肿瘤等疾病的早期阶段发挥着“始动”作用,可介导登革热病毒与树突状细胞的相互作用,增加病毒颗粒的感染力和增殖力;也可以促进肾炎组织中足细胞诱导T细胞增殖的功能;同时通过与B细胞受体的相互作用,能模拟通常由抗体依赖性的BCR接触而产生的功能性信号通路,参与非霍奇金淋巴瘤的病程发展。因而,DC-SIGN在区域免疫和适应性免疫反应中发挥重要功能,本文就DC-SIGN的免疫调节作用及其与临床疾病的关系作一综述。
DC-SIGN is a type II transmembrane protein with glycoconjugation domain that is ubiquitous on the surface of immune cells such as macrophages and dendritic cells. DC-SIGN plays an important role in the early stages of infection, inflammation and cancer, and can mediate the interaction between dengue virus and dendritic cells and increase the virulence and proliferative capacity of virus particles. Promotes the function of podocyte-induced T cell proliferation in nephritis tissue; at the same time, by interacting with the B cell receptor, it is possible to mimic the functional signaling pathway that is normally produced by antibody-dependent BCR exposure and is involved in the non-Hodgkin’s lymphoma Course of development. Thus, DC-SIGN plays an important role in regional immune and adaptive immune responses. This review summarizes the immunoregulatory role of DC-SIGN and its relationship with clinical diseases.