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目的:观察和评价胸腺肽联合短程化疗治疗老年初治涂阳肺结核的疗效。方法:将112例老年初治涂阳肺结核患者随机分为治疗组和对照组,各56例。两组均采用短程标准化疗方案(2H3R3I3E3/4H3R3)治疗。治疗组采用上述化疗方案治疗的同时,加用胸腺肽40mg,臀部肌内注射,每周2次,疗程3个月。观察痰菌阴转、肺部病灶吸收、空洞闭合等情况。结果:痰菌阴转情况:2、5个月、疗程末治疗组分别有54、56、56例阴转,对照组分别有47、50、52例阴转,两组比较有显著性差异(P<0.05)。病变吸收情况:2、4个月、疗程结束后病灶显著吸收病例,治疗组分别为26、45、49例,对照组分别为14、33、40例,两组比较有显著性差异(P<0.05)。空洞闭合情况:2、4个月空洞闭合病例,治疗组分别为12、17例,对照组分别为5、10例,两组比较有显著性差异(P<0.05)。结论:胸腺肽联合短程化疗治疗老年初治涂阳肺结核疗效显著。
Objective: To observe and evaluate the efficacy of thymosin combined with short-course chemotherapy in the treatment of smear-positive pulmonary tuberculosis in the elderly. Methods: 112 elderly patients with newly diagnosed smear positive pulmonary tuberculosis were randomly divided into treatment group and control group, with 56 cases in each. Both groups were treated with short-range standard chemotherapy (2H3R3I3E3 / 4H3R3). Treatment group using the above chemotherapy regimen at the same time, plus thymosin 40mg, buttocks intramuscular injection twice a week for 3 months. Observe sputum negative conversion, absorption of lung lesions, hollow closure and so on. Results: sputum negative conversion: 2,5 months, the end of the treatment group were 54,56,56 cases of negative conversion, the control group were 47,50,52 cases of overcast, the two groups were significantly different ( P <0.05). Lesion absorption: 2,4 months, after the end of treatment significantly absorbed the case, the treatment group were 26,45,49 cases, the control group were 14,33,40 cases, the two groups were significantly different (P < 0.05). Empty closed cases: 2,4 months empty closed cases, the treatment group were 12,17 cases, the control group were 5,10 cases, the two groups were significantly different (P <0.05). Conclusion: Thymosin combined with short-course chemotherapy for the treatment of smear-positive pulmonary tuberculosis in elderly patients with significant effect.