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尽管在近20年内手术技术与放射治疗取得了一定进展,口腔鳞癌在经传统治疗后的残存及复发病变的治疗,仍然是一个难题。常见口腔癌(例如舌癌、口底癌)的5年生存率已接近65％,随着对头颈癌发生中分子事件的深入了解,端粒—端粒酶理论获得了越来越多的支持。正常机体组织(除芽胞系细胞外)不表达端粒酶活性,端粒酶通过维持增殖和阻止细胞死亡而使瘤细胞逃避衰老(senescence)。端粒对于染色体的稳定性和基因表达至关重要,端粒酶与肿瘤转化之间的关
Although surgical techniques and radiotherapy have made some progress in the past 20 years, the treatment of oral squamous cell carcinoma after the traditional treatment of residual and recurrent lesions remains a problem. The 5-year 5-year survival rate of common oral cancers (eg, tongue cancer, floor cancer) is already close to 65% and with increasing insight into molecular events in the development of head and neck cancer, telomere-telomerase theory is gaining more and more support . Normal body tissues (except the germline extracellular) do not express telomerase activity, and telomerase eases tumor cells senescence by maintaining proliferation and preventing cell death. Telomeres are crucial for the stability and gene expression of chromosomes. The relationship between telomerase and tumor transformation