目的研究重症监护病房(ICU)患者深静脉导管相关感染的病原菌分布及耐药性,为临床科学选用抗菌药物提供依据。方法采用回顾性调查方法,对某医院ICU住院患者中疑似静脉导管相关感染(CRBSI)者送检标本病原菌检验结果进行了统计分析。结果 102例疑似静脉导管相关感染患者中确诊CRBSI 44例,感染率为43.1%;股静脉置管患者感染率最高,占52.3%。44例CRBSI患者送检标本中共检出病原菌48株(含混合感染4例),革兰阳性球菌、革兰阴性杆菌和真菌构成比依次为54.17%、29.17%和16.67%。26株革兰阳性球菌对万古霉素、替考拉宁、利奈唑烷均敏感;革兰阴性菌仅对丁胺卡那和替加环素全部敏感。结论 CRBSI病原体以革兰阳性菌为主,且革兰阳性菌和革兰阴性菌耐药性较普遍,仅对少部分抗菌药物敏感。 Objective To study the distribution and drug resistance of pathogenic bacteria in deep venous catheter-related infections in intensive care unit (ICU) patients and to provide basis for the selection of antimicrobial agents in clinical science. Methods The retrospective investigation method was used to analyze the test results of pathogenic bacteria in suspected ICVs of inpatients in a hospital ICU. Results Of the 102 cases suspected of venous catheter-related infections, 44 cases were diagnosed as CRBSI, the infection rate was 43.1%. The infection rate of femoral vein catheterization was the highest (52.3%). Forty-eight CRBSI patients were detected in the specimens were detected 48 pathogenic bacteria (including 4 cases of mixed infection), Gram-positive cocci, Gram-negative bacilli and fungi were 54.17%, 29.17% and 16.67%. 26 Gram-positive cocci were sensitive to vancomycin, teicoplanin and linezolid; Gram-negative bacteria were only sensitive to amikacin and tigecycline. Conclusions Gram-positive bacteria are the main pathogens of CRBSI, and Gram-positive bacteria and Gram-negative bacteria are more common and susceptible to only a few antibiotics.