本文用原位杂交技术动态观察了慢性低氧大鼠肺内原癌基因ｊｕｎ、ｆｏｓ和ｍｙｂ的表达，结果发现：（１）正常大鼠肺内有一定量的ｊｕｎｍＲＮＡ表达，少见到ｍｙｂ及ｆｏｓ的表达；（２）低氧１周时，ｊｕｎ的表达较正常下降，２周后有所增加。低氧３周后，ｊｕｎ的ｍＲＮＡ表达较正常明显上升；（３）低氧１、２周后，ｍｙｂ的表达明显增加，３周时基本恢复到正常水平；（４）ｆｏｓ原癌基因在低氧１、２周时有一定量的表达，低氧３周时达最大值。提示低氧可刺激大鼠肺内原癌基因ｊｕｎ、ｍｙｂ和ｆｏｓ的表达。 In situ hybridization was used to dynamically observe the expression of protooncogene jun, fos and myb in the lungs of chronic hypoxia rats. The results showed that: (1) There was a certain amount of junmRNA expression in the lungs of normal rats, and the expression of myb and fos was rare ; (2) At 1 week of hypoxia, the expression of jun decreased more than normal and increased after 2 weeks. After 3 weeks of hypoxia, jun mRNA expression was significantly increased compared with normal; (3) After 1 week of hypoxia, myb expression increased significantly, returned to normal levels at 3 weeks; (4) fos protooncogene in the low Oxygen a certain amount of expression at 1,2 weeks, hypoxia reached the maximum at 3 weeks. Hypoxia could stimulate the expression of protooncogene jun, myb and fos in rat lung.