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采用微囊化胰岛异种移植治疗实验性糖尿病大鼠，同时观察与常规胰岛素皮下注射在存活率、降血糖、血流变、肝脏超微结构的变化等方面的影响。结果表明，移植组在移植术后７０ｄ 时全部存活，胰岛素治疗组８ 只存活，移植术后１００ｄ 时测得血糖（６．５１±１．０８）ｍ ｍ ｏｌ／Ｌ，与胰岛素注射组（２１．２９±２．４５）ｍ ｍ ｏｌ／Ｌ相比差异有显著性（Ｐ＜ ０．０１）。血流变指标改变如全血高切粘度、低切粘度、细胞聚集指数、高切还原和低切还原粘度等移植组均比胰岛素组降低（Ｐ＜ ０．０５，Ｐ＜ ０．０１）。移植组肝脏超微结构病理改变显著轻于胰岛素治疗组。表明微囊化胰岛移植治疗实验性糖尿病有效，并能降低血流变指标和减缓肝脏的损害，对改善微循环和预防糖尿病并发症有重要作用
Microencapsulated islet xenotransplantation was used to treat experimental diabetic rats. At the same time, the effects of subcutaneous injection with insulin on the survival rate, hypoglycemicmia, hemorheology and liver ultrastructure were observed. The results showed that the transplantation group all survived 70 days after transplantation, 8 survived in the insulin group, and the blood glucose (6.51 ± 1.08) m mol / L at 100 days after transplantation was significantly higher than that in the insulin injection group .29 ± 2.45) m m ol / L, the difference was significant (P <0.01). Changes of hemorrheological indexes such as whole blood high shear viscosity, low shear viscosity, cell aggregation index, high shear reduction and low shear reduction viscosity were all lower than those in insulin group (P <0.05, P <0.01). Pathological changes of the liver ultrastructure in the transplantation group were significantly lighter than those in the insulin treatment group. It shows that microencapsulated islet transplantation is effective in treating experimental diabetes and can reduce the indexes of blood rheology and reduce the damage of the liver and plays an important role in improving the microcirculation and preventing the complications of diabetes