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目的 :应用冠脉血流显像技术检测前降支慢性闭塞后其供血区心肌内冠脉血流信号的变化 ,探讨该技术在评价心肌内侧支循环方面的价值。方法 :2 4只实验小型猪 ,在前降支 (LAD)近端放置 ameroid收缩环建立慢性心肌缺血模型。放环 6周后做选择性左冠状动脉造影 ;分别在基础状态及模型形成后应用冠脉血流显像技术观察左室前壁和室间隔心肌内冠脉血流信号的分布 ,同时记录其血流频谱并测定峰值血流速度 (Vmax) ;比较心肌内冠脉血流在模型形成前后的变化并与冠脉造影结果相对照 ,分析侧支循环的形成。结果 :1 4只动物成功建立模型 ,根据左室前壁和前间隔内有无血流信号 ,将动物分为 A、 B两组 :A组 6只 ,前降支供血区心肌内未见明显血流信号显示 ,冠脉造影亦未见心外膜侧支形成 ;B组 8只 ,前壁和室间隔内可见不同形式的血流信号 ,冠脉造影有 4条见心外膜侧支形成。结论 :冠脉血流显像技术能直观显示冠脉闭塞后其供血区心肌内侧支循环的建立 ,是冠脉造影的重要补充
OBJECTIVE: To assess the changes of intramyocardial coronary flow signals in coronary arteries by coronary flow imaging after chronic occlusion of anterior descending coronary artery (LAD), and to explore the value of this technique in assessing myocardial collateral circulation. Methods: Twenty - four experimental miniature pigs were divided into ameroid systole at the proximal part of the anterior descending artery (LAD) to establish a chronic myocardial ischemia model. The left coronary artery was divided into 6 groups, and the left coronary artery was placed in the left ventricular wall and the left ventricular septal myocardium was observed. Flow spectrum and determine the peak blood flow velocity (Vmax). To compare changes of intramyocardial coronary blood flow before and after the model was established and compared with coronary angiography results to analyze the formation of collateral circulation. Results: One hundred and four animals were successfully established, and animals were divided into A group and B group according to the presence or absence of blood flow signals in the anterior wall of the left ventricle and the anterior septum. There were 6 rats in group A and no significant myocardial infarction Blood flow signals showed that there was no epicardial branch formation in coronary angiography. In group B, 8 different types of blood flow signals were seen in the anterior wall and interventricular septum. There were 4 coronary angiography findings of epicardial collateral formation. Conclusion: Coronary flow imaging can visualize the establishment of myocardial branches in coronary artery after coronary artery occlusion, which is an important complement to coronary angiography