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目的 分析细胞色素氧化酶P450(CYP)酶系中CYP1A1 rs4646903基因多态性与慢性阻塞性肺疾病(简称慢阻肺)易感性的关联强度。方法 检索CNKI数据库、VIP数据库、WanFang数据库、PubMed数据库、Cochrane图书馆及Embase数据库,检索时限从建库开始至2016年1月。査找CYP1A1 rs4646903基因多态性与慢阻肺易感性相关的病例对照研究。采用StataSE 12.0进行数据分析。应用比值比(OR)及其95%可信区间(95%CI)表示其关联强度。结果 共纳入病例对照研究6项,涉及患者1 050例,健康对照1 202例。Meta分析结果显示:累加遗传模型(CC vs.TT,OR=1.63,95%CI 1.17~2.27,P=0.004)、隐性遗传模型(CC vs.TC+TT,OR=1.62,95%CI1.19~2.20,P=0.002)可能是慢阻肺的遗传易感因素。而等位基因模型(Cvs.T,OR=1.20,95%CI0.95~1.51,P=0.118)、显性遗传模型(CC+TC vs.TT,OR=1.19,95%CI 0.82~1.72,P=0.366)可能不会增加慢阻肺的罹患风险。结论 CYP1A1rs4646903基因多态性与慢阻肺易感性相关,且为慢阻肺的危险因素,但还需更多大样本的研究进一步证实。
Objective To analyze the association between CYP1A1 rs4646903 polymorphism and the susceptibility to chronic obstructive pulmonary disease (COPD) in cytochrome oxidase P450 (CYP) enzyme system. Methods CNKI database, VIP database, WanFang database, PubMed database, Cochrane library and Embase database were retrieved. The search time was from the beginning of database construction to January 2016. A case-control study on CYP1A1 rs4646903 polymorphism and COPD susceptibility. Data analysis using StataSE 12.0. The odds ratio (OR) and its 95% confidence interval (95% CI) were used to express the association strength. Results A total of 6 case-control studies were included, involving 1 050 patients and 1 202 healthy controls. Meta analysis showed that the cumulative genetic model (CC vs. TT, OR = 1.63, 95% CI 1.17-2.27, P = 0.004) and the recessive genetic model (CC vs. TC + TT, OR = 1.62, 95% CI1) 19 ~ 2.20, P = 0.002) may be a genetic predisposing factor for COPD. The allele model (Cvs.T, OR = 1.20, 95% CI0.95-1.51, P = 0.118), the dominant genetic model (CC + TC vs. TT, OR = 1.19, 95% CI 0.82-1.72, P = 0.366) may not increase the risk of COPD. Conclusion CYP1A1 rs4646903 gene polymorphism is associated with COPD susceptibility and is a risk factor for COPD. However, further studies with large samples are needed to further confirm this.