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应用放射免疫测定法检测了４０例充血性心力衰竭（心衰）患儿和３０例正常儿童血浆内皮素浓度，对３６例患儿进行了治疗前后动态观察。结果显示心衰患儿血浆内皮素浓度明显高于正常儿童，且与病情轻重有关，心衰程度越重，内皮素浓度越高，心衰治疗好转后内皮素浓度较治疗前明显降低。提示血浆内皮素浓度与心衰严重程度呈正相关。作者认为，在病程中测定血浆内皮素浓度，不仅可用于判断心衰严重程度，而且可作为判断疗效的一个辅助指标。
Plasma concentrations of endothelin were measured in 40 children with congestive heart failure (CHF) and 30 normal children by radioimmunoassay, and 36 children were observed before and after treatment. The results showed that plasma endothelin concentrations in children with heart failure were significantly higher than those in normal children and were related to the severity of the disease. The more serious heart failure was, the higher the endothelin concentration was and the better the endocardial treatment was. Tip plasma endothelin concentration and the severity of heart failure was positively correlated. The authors believe that the determination of plasma endothelin concentration in the course of disease, not only can be used to determine the severity of heart failure, but also as an adjunct to determine the efficacy of indicators.