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为了探寻抗癌活性高、肾毒性小、水溶性较大的新型药物,合成了四种二氨基酸 或其衍生物为配体的顺铂型络合物。其中二氯-α,γ-二氨基戊二酸合铂的毒性(LD_50)与已发表的二氯-α,β-丁二酸合铂相近,但它们的抗癌活性大不相同, 有待于进一步研究。
In order to search for new drugs with high anticancer activity, small nephrotoxicity and large water solubility, four cisplatin-type complexes with two amino acids or their derivatives as ligands were synthesized. Among them, the toxicity of dichloro-α, γ-diaminoglutaric acid platinum (Pt_50) is similar to that of platinum dichloro-α and β-succinate, but their anticancer activities are quite different. further research.