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肝脏是脂质代谢的重要器官,肝中过量的脂质堆积诱导细胞内大量活性氧的生成,引起肝细胞内质网应激、线粒体功能紊乱及脂毒性,这与非酒精性脂肪肝病发生密切相关。非酒精性脂肪肝病除引起肝脏病变及死亡外,还与2型糖尿病、动脉硬化性心脑肾血管疾病及肝外恶性肿瘤密切相关。近年来研究发现骨质疏松、骨密度减低与非酒精性脂肪肝病之间有一定的相关性,一些骨代谢相关因子在非酒精性脂肪肝病不同阶段存在异常,本文主要就骨桥蛋白、骨保护素、骨形成蛋白、骨硬化蛋白及骨膜蛋白与非酒精性脂肪肝病之间关系研究进展进行综述。
Liver is an important lipid metabolism of organs, excessive accumulation of lipid in the liver induced a large number of reactive oxygen species generated within the cell, causing the liver cell endoplasmic reticulum stress, mitochondrial dysfunction and lipid toxicity, which is closely linked with non-alcoholic fatty liver disease Related. In addition to causing liver disease and death, non-alcoholic fatty liver disease is closely related to type 2 diabetes, arteriosclerotic cardiovascular and cardiovascular diseases and extrahepatic malignancies. In recent years, studies have found that osteoporosis, decreased bone mineral density and non-alcoholic fatty liver disease have a certain correlation between some bone metabolism-related factors in the different stages of non-alcoholic fatty liver disease abnormalities, the main osteopontin, bone protection The progress of the research on the relationship between osteopontin, bone morphogenetic proteins, osteocalcin, periostin and nonalcoholic fatty liver disease is reviewed.