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在研究硫酸镁静脉及肌内给药的动力学特征的基础上,设计3种硫酸镁给药方案,并与对照组比较。对46例重度妊高征患者系统观察,优选出最佳给药方案:以5g/30min 静脉滴注,接着以1.5～2.0g/h 恒速静滴维持,总剂量25～30g。该方案经342例临床验证,其中资料完整的133例统计分析,治疗后血压下降,症状改善显著105例占79%,不明显或波动大28例占21%,其中18例测得维持剂量期间血镁浓度<3.5mEq/l,疗效与血镁水平密切相关。浮肿、蛋白尿均有显著改善,对新生儿无异常影响。惟分娩出血率高于正常孕妇组。
On the basis of studying the kinetic characteristics of intravenous and intramuscular administration of magnesium sulfate, three solutions of magnesium sulfate were designed and compared with the control group. 46 patients with severe PIH were observed systematically, and the optimal dosing regimen was optimized: intravenously dripped at 5g / 30min, followed by intravenous infusion at a constant speed of 1.5-2.0g / h for a total dose of 25-30g. The program by 342 cases of clinical validation, of which 133 cases of complete statistical analysis, blood pressure decreased after treatment, symptoms were significantly improved 105 cases accounted for 79%, 28 cases were not significant or fluctuant 21 cases, of which 18 were measured during the maintenance dose Blood magnesium concentration <3.5mEq / l, efficacy and blood magnesium levels are closely related. Edema, proteinuria were significantly improved, no abnormal effects on the newborn. However, the rate of bleeding was higher than normal pregnant women.