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目的评价静脉用地尔硫卓对难治性不稳定型心绞痛(UAP)患者的疗效和安全性。方法选择40例难治性UAP患者,静脉给予地尔硫卓,以50～250μg/min,持续微量泵注入48h,观察心绞痛症状、心电图及血压、心率变化。结果40例UAP患者开始用药后48h内与用药前48h比较,平均心绞痛发作次数减少,平均心绞痛最长时间缩短;血压下降、心率减慢,心肌耗氧量指标降低;治疗后24h和48h心电图缺血性表现明显改善;出现2例窦性心动过缓、1例低血压,经处理后均恢复,头痛及恶心各1例,对症处理后缓解。结论短期静脉用用地尔硫卓为难治性UAP提供一种安全药物治疗手段。
Objective To evaluate the efficacy and safety of intravenous diltiazem in patients with refractory unstable angina (UAP). Methods Forty patients with refractory UAP were enrolled in this study. Diltiazem was intravenously administered to the patients with 50 ~ 250μg / min intravenous injection for 48 hours. The angina pectoris, electrocardiogram, blood pressure and heart rate were observed. Results The average number of angina pectoris and the average angina pectoris time were shortened in 48 UAP patients within 48h after the start of medication. The blood pressure was decreased, the heart rate slowed down, and the myocardial oxygen consumption decreased. After 24 h and 48 h of electrocardiogram Bloody performance was significantly improved; 2 cases of sinus bradycardia, 1 case of hypotension, after treatment were recovered, headache and nausea in 1 case, symptomatic relief after treatment. Conclusion Short-term intravenous diltiazem as a refractory UAP provides a safe drug treatment.