以阿霉素为代表的蒽环类抗生素是十分重要又很有前途的一族抗肿瘤药物。寻找疗效更高、毒性更小的蒽环类抗生素除了通过微生物发酵和半合成之外,尚可借助于全合成方法,根据构效关系设计和合成预期的化合物,以弥补前两者的不足,它已引起药物化学家和有机化学家的兴趣。 Anthracyclines, represented by doxorubicin, are a very important and promising family of antitumor drugs. Looking for more effective and less toxic anthracycline antibiotics in addition to microbial fermentation and semi-synthesis, but also by means of total synthesis, structure-activity relationship between the design and synthesis of the expected compounds to make up for the first two deficiencies, It has drawn the interest of medicinal chemists and organic chemists.