触发性活动(Triggered activity)作为心律失常的细胞学机制之一,近年来日益受到人们的重视。许多工作表明,在能够增加内向电流或减少复极化电流的诸多因素影响下,都可在离体的Purkinje纤维或心室肌上诱发出早发后去极化(Early afterdepola rizations,EADs),即在动作电位复极的2期或3期出现一个非驱动性去极化电位,从而触发出两个以上,甚至连续地去极化活动。但是,在动作电位的复极过程中,利用电刺激触发出持续地去极化活动,尚未见到文献报道。本实验室曾在冬眠型哺乳动物达乌尔黄鼠心室肌上成功地记录了这种多发性去极化活动,其形式与EADs反应颇为相似。这一发 Triggered activity, as one of the cytological mechanisms of arrhythmia, has drawn more and more attention in recent years. Many studies have shown that early afterdepola rizations (EADs) can be induced on ex vivo Purkinje fibers or ventricular myocytes under the influence of many factors that can increase inward current or decrease repolarization current, ie A non-driven depolarization potential appears in phase 2 or phase 3 of repolarization of the action potential, triggering more than two depolarizations, or even depolarizing activity. However, in the process of repolarization of action potentials, the use of electrical stimulation to trigger the continuous depolarization activity has not been reported in the literature. Our lab successfully documented this multiple depolarization activity in the hibernating mammalian daurine ventricular muscle, a form that is quite similar to that of EADs. This hair