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为了取代传统的胰岛素注射剂型,研究设计了不同方法用于克服胃肠道吸收和透皮吸收的内在屏障。过去十年中,大量研究致力于避免对胰岛素多次皮下注射的长期依赖性,改善胰岛素的药物代谢动力学性质。本文综述了胰岛素无创给药系统的发展现状。
In order to replace the traditional insulin injection formulation, different approaches have been developed to design the intrinsic barrier to overcome gastrointestinal absorption and transdermal absorption. In the past decade, a large number of studies have been devoted to avoiding long-term dependence on multiple subcutaneous injections of insulin and improving the pharmacokinetic properties of insulin. This article reviews the current status of insulin noninvasive drug delivery systems.