苦皮藤素Ⅴ是从杀虫植物苦皮藤CelustrusangulatusMax.根皮中分离的一种对昆虫具毒杀活性的新化合物。采用电子显微镜技术研究了苦皮藤素Ⅴ对东方粘虫Mythimnaseparata (Walker)肌肉系统的作用。电镜观察发现 ,苦皮藤素Ⅴ对东方粘虫成虫飞行肌和幼虫体壁肌均具致毒作用 ,中毒试虫肌细胞特别是肌细胞的质膜及内膜系统发生明显病变 :肌膜破坏 ,脱落 ;线粒体肿胀 ,空泡化 ,崩解 ;肌原纤维与线粒体间间隙增大 ;肌质网扩张 ,产生髓鞘样结构 ;细胞核肿胀 ,核质浓缩 ,核膜破坏 ;微气管与肌细胞之间间隙增大 ;肌小节弥散、排列紊乱。这些结果表明 ,肌细胞质膜及内膜系统可能是苦皮藤素Ⅴ的一个作用部位 Celangulin Ⅴ is a new compound isolated from the root bark of the insecticidal plant Celustrus angulatus Max., An insecticidal insecticidal compound. The effect of celangulin Ⅴ on Mythimnaseparata (Walker) muscular system was studied by electron microscopy. Electron microscopy showed that celangulin Ⅴ had a toxic effect on the flight muscle and larvae of the oriental armyworm, and the pathological changes of the plasma membrane and intima of muscle cells, especially myocytes, of the poisoning worms were obvious: , Shedding; mitochondria swelling, vacuolization, disintegration; myofibril and mitochondrial gap increased; sarcoplasmic reticulum dilated, resulting in myelin-like structure; nuclear swelling, nuclear condensation, nuclear membrane destruction; micro-tracheal and muscle cells The gap between the increase; sarcolemmal dispersion, disordered arrangement. These results suggest that the muscle cell plasma membrane and the intima system may be a site of celangulin Ⅴ