A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated intervention.At present,patients (n= 1395) from four communities have completed follow-up for one year,including the intervention group (n=921) and usual care group (n=474).The intervention programs included disease management by a care manager.Blood pressure of each patient was measured regularly.Compared with the control group,the net change of mean systolic blood pressure (SBP) was -6.75 (95% CI:-7.79 to-5.71,P＜0.001) mmHg,mean diastolic blood pressure (DBP) was-4.29 (95% CI:-5.08 to-3.49,P＜0.001) mmHg,and mean pulse pressure (PP) was-2.46 (95% CI:-3.50 to-1.43,P＜ 0.001) mmHg in the intervention group.The net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological treatment.The measures of integrated intervention for hypertension patients in communities can lower significantly not only SBP and DBP,but also PP.It is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.